Clinical Laboratory Sciences Syllabi


Syllabus for CLLS 6307
Molecular Diagnostics
Instructor:Jianzhi Zhang, M.D., M.S., M(ASCP)
Contact Information:Office: SHP 4.432
Phone: (409) 772-9473
Course Description:The Clinical Laboratory Sciences course, Molecular Biology, is designed to provide the student with an understanding of cellular physiology as a background to facilitate an understanding of the processes which have been collectively referred to as molecular biology. With the advent of biotechnology many aspects of molecular biology have been exploited to provide molecular tools which can be used in the clinical laboratory, research laboratory and industrial setting. The goal of this course is to provide the student with a practical theoretical background in molecular biology which will promote critical thinking and problem solving as it relates to molecular diagnostics.
Cognitive & Psychomotor Objectives:Upon completion of this course, the student will be able to:

1) familiarize themselves with many of the basic concepts of molecular biology, including but not limited to DNA replication, transcription, translation, DNA damage and repair, mutagenesis, and genetic exchange;

2) Perform experiments which will foster scientific inquiry into basic principles of molecular methods including DNA isolation, DNA sub-cloning, bacterial transformation, restriction digestion of DNA, protein expression, isolation and western blotting.

3) Perform a number of clinically relevant procedures including DNA fingerprinting which involves isolation and analysis of human chromosomal DNA utilizing techniques such as DNA transfer and hybridization. Additionally, polymerase chain reaction based analysis of infectious disease will be investigated.

4) perform accurately all routine procedures utilized during the course, by completion of the unit in which they are presented, as well as describe laboratory-induced errors for each type of procedure

5) correlation of laboratory findings with the patient’s clinical signs and symptoms using graduate level case studies and journal discussion

Affective Objectives:Professional conduct such as teamwork, respect for colleagues, confidentiality, adhering to safety protocols, and ethical responsibility are expected of each student in both the lecture & laboratory components of the course. For each failure to comply there will be a 2% decrease in the final course grade. Participation in discussion board and case study presentation is expected. Excused absences are for personal illness and/or incapacitation. Other absences will be determined as excused or unexcused at the discretion of the instructors. Unexcused absences will result in a 2% reduction of the final course grade for each absence.
Methods of Evaluation:

Grading Scale for this course is: 



90% - 100%


Lab Exercises


80% - 89%


Laboratory Quizzes (2)


79% and below


Lecture Exams (2)




Final Lecture Exam




Final Laboratory Exam




Case study




The grades are determined as follows:

Lecture:  Three exams will be given including the final exam. All exams are comprehensive.
Laboratory:  Three exams will be given including the final. All exams are comprehensive.


General Policies of the School of Health Professions

Academic Progress:Information regarding the Student's academic progress in this course will be shared with their Academic Advisor and/or Department Chair. Student's making unsatisfactory progress will be referred to the Office of Student Affairs for assistance.
Academic Integrity:Academic dishonesty includes, but is not limited to, cheating, plagiarism, collusion, the submission for credit of any work or materials that are attributable in whole or in part to another person, taking an examination for another person, and any act designed to give unfair advantage to a student or the attempt to commit such an act. Procedures to be followed in the event of alleged academic dishonesty are described in the Rules and Regulations of the Board of Regents of The University of Texas System, and the SAHS Student Handbook. Alleged academic dishonesty issues should be reported to the Student Affairs Officer.
Professional Behavior:As a part of a professional program, you are expected to conduct yourselves in a manner consistent with the level of trust and responsibility that will be placed on you when you are part of a health care team. You are expected to be honest in your dealings with your instructor and your peers. You are also expected to be able to follow instructions, to act with the utmost integrity, to follow safety protocols while in laboratory, to perform laboratory work with care, and to act in accordance with those standards characteristic of those we call "professionals."
Behavior during examinations, written and practical, will be monitored. Inappropriate behavior may result in pursuance of disciplinary action.
University Statement on Equality, Tolerance, and Affirmative Action:Please indicate by the end of the second week of the semester if you will need accommodations under the Americans with Disabilities Act (Public Law 101-336). If the need for ADA accommodations should arise during the semester you will need to make your request within one week of returning to classes. You may contact your Instructor or the Office of Student Affairs.
Course Evaluation:Students will be given the opportunity to evaluate the instructor and course near the end of the course/semester. When submitting course evaluations students must follow the guidelines provided by the course instructor or the department.
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