Clinical Laboratory Sciences Syllabi


Syllabus for CLLS 4415
Immunology / Immunohematology
Instructor:LeeAnn Walker, MEd; MT(ASCP) SBB
Contact Information:Office: SHP 4.436
Phone: 772-9477
Course Description:The purpose of this class is to provide the student with the opportunity to demonstrate: 1) an understanding of the role of both humoral and cellular immunity in defense against disease as well as in situations where the immune mechanisms are functioning abnormally; 2) perform, evaluate the results of, and trouble shoot the more advanced immunochemical and immunoassay techniques; 3) perform, evaluate the results of, and interpret immunohematology techniques in situations including but not limited to incompatibility, transfusion reactions, hemolytic anemias, and multiple antibodies. Prerequisite course: CLLS 3310 Serology & Blood Banking or its equivalents.
Course Objectives:

Upon completion of the this course, the student will be able to:

  1. Apply the basic concepts and procedures of Immunohematology to determine the RBC antigens of the major blood group systems.
  2. Determine the identity and clinical significance of unexpected antibodies via their characteristics.
  3. Correlate in vitro behavior of RBC antigens and antibodies with the pathological states they may produce clinically.
  4. Apply donor information from screen and interview to determine the safety of the donation for both donor and recipient.
  5. Describe proper technique for donor interview, preparation for collection of units, post-phlebotomy care and preparation of blood components from whole blood donations.
  6. Categorize blood components according to preparation, quality control, and therapeutic use.
  7. Compare; contrast the inflammatory response, humoral, and cellular; immunity in response to bacteria, fungi, viruses, and allogenic cells.
  8. Delineate the mechanisms that permit cellular immunity and immunoglobulins to involve other cells and mediator systems in eliminating antigenic threats.
  9. Interpret as well as perform and/or describe the methodologies used in clinical settings to evaluate humoral and cellular immunity.
  10. Compare and contrast the more commonly occurring autoimmune diseases in terms of general pathology as well as clinical tests utilized in their differentiation.
  11. Demonstrate professional behavior through working both independently and in groups to solve problems and perform analyses.
  12. Organize laboratory work areas and tasks in such a way as to accomplish laboratory assignments and unknowns efficiently in preparing to meet patient needs.
  13. Establish work habits and ethics which represent an understanding of the behaviors needed to provide optimum care for the patient population.
  14. Internalize social values and behaviors to permit him/her to function effectively with culturally and individually diverse peers to create an effective work environment.
Affective Objectives:Students will be given the opportunity to demonstrate the development of behaviors and attitudes consistent with those of the profession. Evaluation of these behaviors will be performed using the Affective Objectives and Evaluation checklist in the Orientation Handbook. The student should successfully meet these objectives a minimum of 70% of the time for satisfactory completion of this course. Certain criteria on the checklist are more specific. Students must meet those criteria at the level indicated on the checklist.
Required Course Materials:

Textbook: Harmening, D.M.: Modern Blood Banking and Transfusion Practices, 5th Edition and Stevens, Christine: Clinical Immunology and Serology, 3rd Edition.

Method of Evaluation:

Course Activities and Weighting

Grading Scale 

3 Lecture Exams @ 100 each


Class Attendance/ Participation; 4 Case Presentation Participation @
25 total


2 Quizzes at 50 points each


4 Laboratory Unknown/Lab Exams @ 100  


Comprehensive Lab Practical @ 150 points


Comprehensive Lec. Final Exam @ 150 points 12.5%



Course Policies:

STUDENT RESPONSIBILITY: Students will be expected to attend class, take notes, and participate in class discussions and laboratory activities. All classes require participation on one form or another. You are expected to come to class on time and ready to participate in designated activities. Due to the structure of most courses, laboratory make ups may not be possible. If a student misses a class, it is their responsibility to get handouts and notes from a fellow classmate. Makeup tests will be given only if prior approval has been acquired from the instructor. Faculty will follow the CLS Attendance and Participation policy found in the Orientation Handbook.

Attendance is expected in both lecture and laboratory sessions. In the event of an unavoidable absence, the student must notify the instructor. Students not attending will have points deducted from their attendance and participation grade. In addition, laboratory and small group activities will be completed in class. There will be no makeup for these projects without prior approval in the instructor. It is expected that assignments will be turned in at the beginning of the class period on the due date. Late assignments will have points deducted from them.

SAFETY: Students must wear laboratory coats and gloves during laboratory sessions. Shorts and open toed shoes are not allowed. No food or drink will be allowed in the laboratory. All materials must be disposed of properly and tables disinfected before leaving the laboratory. All reusable supplies must be placed on the carts and papers turned in before leaving the laboratory.


General Policies of the School of Health Professions

Academic Progress:Information regarding the Student's academic progress in this course will be shared with their Academic Advisor and/or Department Chair. Student's making unsatisfactory progress will be referred to the Office of Student Affairs for assistance.
Academic Integrity:Academic dishonesty includes, but is not limited to, cheating, plagiarism, collusion, the submission for credit of any work or materials that are attributable in whole or in part to another person, taking an examination for another person, and any act designed to give unfair advantage to a student or the attempt to commit such an act. Procedures to be followed in the event of alleged academic dishonesty are described in the Rules and Regulations of the Board of Regents of The University of Texas System, and the SAHS Student Handbook. Alleged academic dishonesty issues should be reported to the Student Affairs Officer.
Professional Behavior:As a part of a professional program, you are expected to conduct yourselves in a manner consistent with the level of trust and responsibility that will be placed on you when you are part of a health care team. You are expected to be honest in your dealings with your instructor and your peers. You are also expected to be able to follow instructions, to act with the utmost integrity, to follow safety protocols while in laboratory, to perform laboratory work with care, and to act in accordance with those standards characteristic of those we call "professionals."
Behavior during examinations, written and practical, will be monitored. Inappropriate behavior may result in pursuance of disciplinary action.
University Statement on Equality, Tolerance, and Affirmative Action:Please indicate by the end of the second week of the semester if you will need accommodations under the Americans with Disabilities Act (Public Law 101-336). If the need for ADA accommodations should arise during the semester you will need to make your request within one week of returning to classes. You may contact your Instructor or the Office of Student Affairs.
Course Evaluation:Students will be given the opportunity to evaluate the instructor and course near the end of the course/semester. When submitting course evaluations students must follow the guidelines provided by the course instructor or the department.
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