Clinical Laboratory Sciences Syllabi


Syllabus for CLLS 5406
Clinical Chemistry I
Instructor:Muneeza Esani, Ph.D., MPH, MT(ASCP)
Contact Information:Office: SHP 4.426
Phone: 409-772-9456
Course Description:This course is designed for clinical laboratory students to gain an understanding of the principles and components of instrumentation, laboratory calculations, quality assurance and statistics relevant to the medical laboratory. They will also acquire knowledge of metabolism, principles of methodology and interpretation of analytical results for carbohydrates, proteins, lipids, enzymes and electrolytes. Emphasis is also placed on disease processes and pathological conditions which affect body systems, in particular the kidneys and the liver. Laboratory skills will also be gained to reinforce principles of analysis that can be applied to a clinical laboratory setting.
Course Objectives:Upon completion of this course the student will be given the opportunity to demonstrate the ability to:
  1. Describe the major constituents in body fluids (plasma and urine), source, regulation and methods of analysis of electrolytes, carbohydrates, lipids and proteins.
  2. Correlate diseases and conditions that result in glucose, mineral, lipid and protein disturbances with laboratory findings and classify them using standard terminology.
  3. Explain thoroughly the common methodology of analysis and instrumentation involved in detection of BUN, creatinine, uric acid, bilirubin, liver, cardiac and miscellaneous enzymes, glucose, total protein, electrolytes lipids and lipoproteins in terms of general principles, acceptable types of specimens and pre-analytical variations as well as sources of error in test systems.
  4. Recognize laboratory data and quality control data that indicate potential problems in test systems for renal function, liver function tests or serum enzymes, discussing mechanisms of action to resolve these issues.
  5. Characterize enzymes, relating to methods of quantification by kinetic methods.
  6. Correctly perform the following calculations and compare to expected results: enzyme activity given spectrophotometric kinetic data, indirect bilirubin, creatinine clearance, A/G ratio and 24 hour urinary protein levels.
  7. Briefly discuss inter-departmental coordination and regulations involved in obtaining and transporting specimens to centralized laboratories as they relate to electrolytes, renal function, liver function and enzyme testing.
  8. Evaluate typical laboratory data given serum enzymes, total protein, fasting glucose, lipid profile, minerals, bilirubin, creatinine, BUN, uric acid, creatinine clearance correlating the findings with typical clinical conditions.
Course Policies:
  1. It is the student's responsibility to attend class. Should the student be absent from a class, the student is responsible for obtaining the information presented during the session either from another student and by the handouts provided on the world wide web program. An absence from the laboratory must be excused from the laboratory instructor in order to be allowed a chance to make up the exercise. Due to limited use of reagents, time and laboratory space, make-up laboratories are not guaranteed. Important safety issues must be adhered to in the laboratory setting. Students must wear laboratory coats and gloves during laboratory sessions. Shorts and open toed shoes are not allowed. No food or drink will be allowed in the laboratory. All materials must be disposed on properly and tables disinfected before leaving the laboratory. All reusable supplies must be placed on the carts and papers turned in before leaving the laboratory.
  2. Examinations will be given according to the schedule presented in the course calendar. In the unusual circumstance that a true emergency arises, as deemed appropriate by the instructor and the program director, the student must notify the department secretary by phone call and the instructor (by email) within 24 hours of the scheduled time and a make-up examination will be provided within six calendar days, to be given at the convenience of the instructor and the student. The format of the make-up exam will most likely be essay. Failure to take the make-up exam within the scheduled time will result in receiving a zero for that grade.
  3. Textbook reading assignments and lecture notes will be provided for each topic of study. It is the responsibility of the student to read the materials prior to the scheduled lecture, with the exception of the first class meeting. If the student is having difficulty in understanding the reading material, an appointment should be made with the instructor to obtain clarification.
  4. Method of Instruction will include lecture, laboratory exercises, small group discussions, demonstrations and independent reading assignments.
Grading:Examinations, class discussions and exercises will be used to assess competence in this subject and the student will be evaluated in terms of a final percentage grade determined from the points earned divided by the total possible points available. Evaluation of learning will be based according to the following in order to determine the final grade for the course:

Learning ActivitiesGrading
Examination 1100
Examination 2100
Examination 3100
Final Examination100
Required Course Materials:S.C. Anderson and Cockayne, S, Clinical Chemistry: Concepts and Applications, W.B. Saunders, Co., 1993, ISBN 0721633722.


General Policies of the School of Health Professions

Academic Progress:Information regarding the Student's academic progress in this course will be shared with their Academic Advisor and/or Department Chair. Student's making unsatisfactory progress will be referred to the Office of Student Affairs for assistance.
Academic Integrity:Academic dishonesty includes, but is not limited to, cheating, plagiarism, collusion, the submission for credit of any work or materials that are attributable in whole or in part to another person, taking an examination for another person, and any act designed to give unfair advantage to a student or the attempt to commit such an act. Procedures to be followed in the event of alleged academic dishonesty are described in the Rules and Regulations of the Board of Regents of The University of Texas System, and the SAHS Student Handbook. Alleged academic dishonesty issues should be reported to the Student Affairs Officer.
Professional Behavior:As a part of a professional program, you are expected to conduct yourselves in a manner consistent with the level of trust and responsibility that will be placed on you when you are part of a health care team. You are expected to be honest in your dealings with your instructor and your peers. You are also expected to be able to follow instructions, to act with the utmost integrity, to follow safety protocols while in laboratory, to perform laboratory work with care, and to act in accordance with those standards characteristic of those we call "professionals."
Behavior during examinations, written and practical, will be monitored. Inappropriate behavior may result in pursuance of disciplinary action.
University Statement on Equality, Tolerance, and Affirmative Action:Please indicate by the end of the second week of the semester if you will need accommodations under the Americans with Disabilities Act (Public Law 101-336). If the need for ADA accommodations should arise during the semester you will need to make your request within one week of returning to classes. You may contact your Instructor or the Office of Student Affairs.
Course Evaluation:Students will be given the opportunity to evaluate the instructor and course near the end of the course/semester. When submitting course evaluations students must follow the guidelines provided by the course instructor or the department.
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